Abdullah ibn Umar (Radi-allahu-anhu) narrates that when Rasulullah (Sallallahu-alaihi-wasallam) used to mount his animal for setting out on a journey, he would say اللهُ أَكْبَرُ (Allahu-Akbar - Allah is Great) three times and then pray:
سُبْحَانَ الَّذِيْ سَخَّرَ لَناَ هَذَا وَمَا كُنَّا لَهُ مُقرِنِيْنَ وإِنَّا إِلَى رَبِّناَ لمُنْقَلِبُوْنَ ،
اَلَّلهُمَّ إنَّا نَسْألُكَ فِيْ سَفَرِناَ هَذَا البِرَّ وَالتَّقْوَى ومِنَ العَمَلِ ماَ تَرْضَى اَلَّلهُمَّ هَوِّنْ عَلَيْناَ سَفَرَناَ هَذَا وَاطْوِ عَنَّا بُعْدَهُ. الَلَّهُمَّ أَنتَ الصَّاحِبُ فِيْ السَّفَرِ والخَلِيفَةُ في الأَهْلِ الّلهُمَّ إنِّي أَعُوذُ بِكَ مِنْ وَعْثاءِ السَّفَرِ وكَآبَةِ المَنْظَرِ وسُوْءِ المُنْقَلَبِ في المَالِ والأَهْلِ
"Glory to him, Who Has made this (transport) subservient to us, and we ourselves would not have been capable of that, and verily to ou Rabb do we return. O Allah, we ask You for birr and taqwaa in this journey of ours, and we ask You for deeds which please You. O Allah, facilitate our journey and let us cover its distance quickly. O Allah, You are The Companion on the journey and the one who looks after the family, O Allah, I seek refuge with You from the difficulties of this journey, and of witnessing undesirable events and finding undesirable changes in property and family on return" And when he would return from a journey, he used to say the same words and made this addition:
آئِبُوْنَ تَائِبُوْنَ عَابِدُوْنَ لِرَبِّناَ حَامِدُوْنَ.
‘We are returning, repenting, worshiping and praising our Rabb'
(Muslim)